Doctor recommended with over 30 years of experience; REFRESH Family of Products, Ipsos Healthcare, 2021 REFRESH ECP Recommendation Survey.Long-lasting relief plus protection. Patented formula with Purite. No. 1 doctor recommended eye drop brand. For mild-to-moderate dry eye. Refresh Tears Lubricant Eye Drops restores the moisture your eyes crave with a special formula that has many of the same healthy qualities as your won natural tears. What Can Cause Dry Eye? Heating and air conditioning; Computer use and reading; Wind and sun; Certain medications; Natural aging process. Instructions-Directions- Instill 1 or 2 drops in the affected eye(s) as needed.